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KMID : 0378019810240050079
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New Medical Journal
1981 Volume.24 No. 5 p.79 ~ p.96
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An Experimental Study on the Effect of Ginseng upon Atherosclerosis
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Abstract
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As the spans of our lives have been signficantly lengthened through the epoch-making development of science, atherosclerosis which is often found in aged individuals has be,come a target problem in modern medicine. But the pathogenesis of atherosclerosis and its mechanism have not been settled yet.
While ginseng has been traditionally :used as a rejuvenation remedy and marvelous tonic in Asia, its effects have not been scientifically studied with the exception of a few experimental investigations dealing with the infulence of ginseng upon lipid metabolism.
The investigation has been undertaken to evaluate the effect of ginseng upon hypercholesterolemia and atherosclerosis. Sixty healthy rabbits weighing about 2kg were used for this experiment and divided into the following 4 groups;
1. Control group fed with basic diet
2. Cholesterol administered group treated with lipid diet
3. Cholesterol and ginseng administered group treated with lipid "diet added ginseng tiextract
4. Ginseng administered group treated with basic diet plus ginseng extract.
The basic diet was composed of 750gm bean residue and 150gm vegetatable per rabbit per day. The lipid diet was the basic diet to which 500mg of cholesterol per kg of rabbit lead been added per day. 250mg of ginseng were added to the appropriate group´s diet each day.
Aorta and coronary arteries were examined grossly and microscopically, and the serum cholesterol level in each rabbit was measured.
1. It was found that the serum :cholesterol levels were markedly elevated in those rabbits treated with lipid diet.
2. The elevation of serum cholesterol levels in the rabbits treated with both cholesterol and ginseng extract was lower than that of the cholesterol administered group. The aorta and coronary arteries revealed various degree of atherosclerotic changes in the cholesterol administered group. Atheromatous changes which were also developed in the 3ipid and ginseng administered group were, however, less significant than those in the
cholesterol administered group.
3. No significant changes were noted in both control and ginseng administered groups. The data obtained from this experiment indicated that ginseng may reduce atheromatous changes as well as lower abnormally elevated serum cholesterol levels.
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KEYWORD
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